Mooren's Ulcer

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Original article contributed by: Frank S. Hwang, MD, Abdala Sirajeldin
All contributors: Frank S. Hwang, MD
Assigned editor:
Review: Assigned status Up to Date by Frank S. Hwang, MD on August 4, 2015.



Mooren's Ulcer
Classification and external resources
Mooren’s ulcer.  A crescent-shaped ulceration with an overhanging central edge and a vascularized base is seen in in the temporal periphery of the cornea. Ⓒ 2014 American Academy of Ophthalmology.

Figure 1. Mooren’s ulcer. A crescent-shaped ulceration with an overhanging central edge and a vascularized base is seen in in the temporal periphery of the cornea. Ⓒ 2014 American Academy of Ophthalmology.

ICD-10 H16.0


Disease Entity

Mooren’s ulceration (MU) is characterized by painful peripheral corneal ulceration of unknown etiology. The disease generally begins with intense limbal inflammation and swelling in the episclera and conjunctiva [1]. Corneal changes begin 2-3 mm from the limbus, first appearing as grey swellings that rapidly furrow, affecting the superficial one-third of the cornea and then proceeding circumfrentially and centrally over 4-12 months [1],[2]. The bed of the furrow becomes vascularized, with vessels advancing into the base of the undermined edges of the ulcers [1] (figure 1). These ulcers are often described as crescent-shaped and can leave behind either an opaque, edematous central cornea. Alternatively, they can completely consume the corneal stroma and replacing it with a thin fibrovascular membrane [3]. Inflammation is not seen in in the sclera adjacent to the peripheral ulcers, nor does it affect the underlying Descemet’s membrane [4]. Destruction of the cornea generally affects stromal tissue only, leaving behind an intact endothelium and epithelium [5]. The central edges of the ulcer can develop an overhanging edge with or without opacification, and neovascularization of the cornea can occur, extending from the limbus into the ulcer bed [3]. Neovascularization can occur up to the advancing edge of the ulcer but not beyond it [5].

Etiology

Although the etiology for Mooren’s ulcer (MU) is unknown, there is evidence suggesting an autoimmune basis. Gottsch and colleagues have suggested that this disorder can result from a host response to calgranulin C, a normally hidden antigen expressed by keratinocytes in the corneal stroma [6]. This molecule has also been found in circulating polymorphonuclear leukocytes [5]. Receptors for this antigen have also been found on the surface of certain helminths, which has led to speculation regarding an association with helminthic infections. However, MU has not been proven to be more prevalent in endemic areas of ascariasis [4].

It has been found that certain HLA alleles may be associated with MU. One study suggested that 83% of patients (n=12) with MU were HLA-DR17(3) positive, and 83% were HLA-DQ2 positive, as compared to control populations where frequencies varied between 5% and 40% [5]. The same study found that only one out of 10 patients with another form of destructive sclerokeratitis expressed the HLA-DR17(3) allele and three expressed HLA-DQ2. HLA-DQ5 has also been found in increased frequencies in patients with MU [7].

Risk Factors

Risk factors for MU include corneal surgery, previous trauma, and infection. Although corneal surgery is a well-described risk factor, one study of 242 eyes affected with MU in South India described an interesting caveat. In this study, Srinivasan and colleages described 36 eyes that developed ulceration following extracapsular cataract extraction through a superior limbal incision; however, only 31% of these eyes developed ulceration at or contiguous to the site of the surgical wound. Nevertheless, this ratio of superior corneal involvement of MU is still higher than expected when compared with 10% superior involvement found in eyes with no history of ocular surgery.

An association has also been demonstrated between Mooren’s ulceration and hookworm infection [8]. Certain helminths express receptors for calgranulin C, suggesting that there may be a helminthic antigen that cross-reacts with calgranulin C [5]. Previous infection has also been found to be a risk factor [9].

An association with pyoderma gangrenosum has also been described, implying a potential common pathogenesis to the two processes since both pyoderma gnagrenosum and MU show aseptic neutrophilic inflammation and both respond well to immunosuppression [10].

Epidemiology

Mooren’s ulceration is a rare disease. One study approximated the incidence to be 0.03% in China [2]. The disease is more common in the southern hemisphere including southern and Central Africa and India, indicating a genetic and/or geographic predisposition [5]. Although it is generally agreed upon that MU is more common in men, figures differ from one geographic population to the next in terms of age distribution.

Studies from South India and China have suggested that patients tend to be affected between their sixth and eighth decades of life, with men being affected more than women by a ratio between 1.6:1 to 5:1 [3],[8],[9],[11][12]. However, this epidemiological picture may differ in African populations, as suggested by a study in Nigeria where the disease mostly affected men in their 20s-30s [13]. Another study from West Africa supported this epidemiologic finding, causing the authors to postulate that there were two distinct populations of patients with MU [14]. The first population is older, more often develops unilateral disease, and responds to treatment whereas the second population is younger, tends to have bilateral disease which perforates more often and does not respond well to treatment. Further studies consisting of patients from the Republic of Zaire, Togo, and Sierra Leone further supported this hypothesis [3]. However, the categorization described by Wood and Kaufman has been refuted by others that found bilateral disease to be more common in older patients [15].

General Pathology

Figure 2     Lymphocytic infiltration and neovascularization of the cornea near an area of MU.  (Reproduced from Chen et al. [2] with permission from the British Journal of Ophthalmology.)
On histological examination (figure 2), samples of conjunctival and corneal specimens show a lymphocytic infiltration along with neutrophils, eosinophils, plasma cells, and mast cells [4],[16] . High levels of proteolytic enzymes have been found in affected conjunctival tissue [16]. When the limbal cornea is examined, it can show vascularization and infiltration plasma cells and lymphocytes into the superficial stroma in addition to destruction of the collagen matrix [4]. The midstroma may show disorganized collagen lamellae and hyperactive fibroblasts while the deep stroma contains a macrophage infiltrate. The leading edge of the ulcer can show neutrophilic infiltration with evidence of degranulation. Adjacent conjunctiva may show a hyperplastic epithelium and subconjunctival lymphocytic and plasma cell infiltration [4].

Pathophysiology

It has been postulated that Mooren’s ulceration may result from an autoimmune etiology. Sensitization to calgranulin C, an antigen expressed by corneal stromal keratinocytes, may occur after trauma or infection of the cornea, causing unveiling of this hidden corneal antigen [5]. Unveiling of the hidden antigen may also occur naturally in predisposed people with age. It has been hypothesized that antigen-presenting cells at the limbus can present the unveiled self-antigens via certain HLA class II molecules to T-cells, priming them. Alternatively, antigen-presenting cells may present a helminthic antigen that cross-reacts with calgranulin C (since certain helminths express receptors that bind calgranulin C) resulting in a similar reaction [5]. Later, upon injury of the cornea, humoral and cellular responses result in MU [4],[5].

Martin and colleagues have suggested that infection, trauma, or a systemic disease can expose corneal antigens and stimulate an immune response in which complement is activated and neutrophils degranulate and release collagenases. Collagenases then destroy the corneal stroma, further perpetuating the process by exposing more altered corneal antigens. Eventually, the entire cornea becomes consumed [17]. Evidence for a humoral immune response comes from a study that found circulating IgG against corneal and conjunctival epithelium in patients with MU [18]. Studies have also found antibodies and complement bound to conjunctival epithelium in addition to elevated serum IgA levels [4].

Diagnosis

Figure 3     (A) Partial peripheral Mooren’s ulcer with a descemetocele within.  Conjunctival and episcleral injection is present along with deep vessels in the base of the ulcer.  A characteristic overhanging central ulcer margin is also seen.  (B)  Total peripheral Mooren’s ulcer with an edematous, opacified central cornea.  (C) Complete Mooren’s ulcer where a fibrovascular membrane has replaced the corneal stroma.  (Figure reproduced from Srinivasan, Zegans, Zelefsky, Kundu, Lietman, Whitcher, and Cunningham [3] with permission from the British Journal of Ophthalmology.)  
The diagnosis of MU requires the absence of any ocular infection or systemic rheumatological diseases known to cause peripheral corneal ulceration [3]. Srinivasan and colleages described three patterns of ulceration: partial peripheral, complete peripheral, and total corneal ulceration (Figure 3). In complete peripheral ulceration, the disease process has completely encompassed the corneal periphery, leaving behind a “central island of cornea” that is often opacified (Figure 3b). In total corneal ulceration, the corneal stroma has been completely replaced with a fibrovascular membrane (Figure 3c). Partial peripheral ulceration can be sub-divided into nasal, temporal, superior, and inferior ulceration, of which, temporal and nasal (the so-called intrapalpebral cornea) involvement is more common [3].
Figure 4 Unilateral MU. Early venous phase of angiography shows intense vascular leakage from deep limbal vessels. Non-perfusion of superficial capillary and venous vessels is also seen. Non-perfusion of the superficial limbal vasculature in addition to disruption of the limbal arcade in the area ahead of the advancing ulcer is seen. (Reproduced from Watson [1] with permission from the British Journal of Ophthalmology.)
Watson and colleagues classified the disease into three types based on clinical features, anterior segment fluorescein angiographic findings, and treatment response [1]: The first type, unilateral Mooren’s ulceration (figure 4), is excessively painful and occurs in elderly (>60 years old) patients. Affected eyes are seen to be red and congested but inflammation does not extend beyond 3 mm from the limbus. Vascularization of the ulcer bed is seen along with leakage at the tips of these new vessels. Ulceration extends around the globe and often leaves a thick, opaque central cornea. The central corneal stroma eventually is removed completely and a thin layer of scar tissue remains overlying an intact endothelium and covered by an epithelium derived from conjunctiva. When the stroma disappears, the pain subsides. If scar tissue retracts to the point where Descemet’s membrane is exposed, it is likely that the same process will recur if corneal transplant in performed [1]. Anterior segment fluorescein angiography shows venular occlusion of local episcleral and conjunctival blood vessels along with disruption of the limbal arcade and vascular leakage from deep vessels at the limbus and base of the ulcer. In addition, vaso-obliteration of superficial vascular networks is characteristic of unilateral Mooren’s ulceration.

The second type, bilateral aggressive Mooren’s ulceration, occurs more in younger patients (between ages 14 and 40) and presents with pain that is less severe than in unilateral Mooren’s ulceration [1]. These patients may present with an ulcer in one eye and conjunctival congestion in the other, which eventually progresses to develop grey patches within the corneal stroma about 2 mm from the edge of the limbus. These grey patches then aggregate and lead to a typical MU that progresses first

Figure 5     Bilateral Aggressive MU.  On angiography (b), inflammation and leakage from deep limbal vessels in addition to extension of vessels into the base of the ulcer is seen.  The superficial vascular plexus is dilated but perfused normally.  (Reproduced from Watson [1] with permission from the British Journal of Ophthalmology.)

circumferentially and then centrally. Fluorescein angiography (figure 5) shows vascular leakage and new vessel formation that reaches the base of the ulcer. Angiography can also show changes in the architecture of episcleral vessels and blockage in addition to break-up of the limbal arcade. The superficial vascular plexus remains perfused although it may be dilated.

The third type, bilateral indolent Mooren’s ulceration (figure 6), occurs in middle-aged (mid-50s) patients who exhibit corneal guttering in both eyes with little inflammation. Although both eyes tend to be involved at presentation, the disease is often more severe in one eye and patients complain of discomfort rather than pain [1]. Most cases are gradually progressive but some heal spontaneously. Others may reactivate after a long period of quiescence. Vascular architecture in this type is normal with the exception that new vessels may extend into the base of the ulcer [19].

Figure 6     Bilateral indolent MU with perforation at 12 o’clock (a).  Angiography at the ulcer’s advancing edge shows no changes in superficial vessel architecture.  Mild vasodilation is noted in the region of the ulcer.  (Reproduced from Watson [1] with permission from the British Journal of Ophthalmology.)

History and Physical examination

Patients often experience severe pain, photophobia, and tearing along with a red inflamed eye. About one third of cases present bilaterally [19]. Slit-lamp examination may reveal a crescent-shaped peripheral corneal ulcer with an undermined central edge. A linear epithelial defect may develop at the central margin, followed by progressive stromal melting. The ulcer progresses both circumfrentially and centrally, resulting in a re-eipithelialised, conjunctivalised thinned cornea [19]. Consequently, severe irregular astigmatism may result. Conjunctival and episcleral inflammation may occur; however, the sclera is spared. Decreased visual acuity can occur secondary to iritis, central corneal involvement, or irregular astigmatism [4].

Differential diagnosis

To rule out other causes of peripheral ulcerative keratitis (http://eyewiki.org/Peripheral_Ulcerative_Keratitis), laboratory investigations include CBC with differential, platelet count, ESR, rheumatoid factor, complement fixation, ANA, ANCA, circulating immune complexes, LFT’s, VDRL/FTA-ABS, BUN and creatinine, serum protein electrophoresis, and urinalysis [4]. In addition, cultures should be performed to rule out microbial keratitis.

Terrien’s marginal degeneration differs from Mooren’s ulceration in that it is a painless, noninflammatory disease causing peripheral corneal thinning without ulceration. Terrien’s degeneration also usually begins in the superior cornea (rather than the interpalpebral region) and proceeds circumfrentially but not centrally. A clear zone with superficial vascularization remains between the limbus and the infiltrate [4].

Pellucid marginal degeneration causes inferior corneal thinning and causes irregular against-the-rule astigmatism but lacks the inflammation and pain seen in MU [4]. Senile furrow degeneration causes thinning between the limbus and an arcus in elderly patients; however, no inflammation or vascularization occurs [4].

Rheumatoid arthritis (RA) can cause peripheral corneal ulcers that start as grey, swollen areas within 2 mm of the limbus [1]. Corneal thickness diminishes rapidly and may leave behind a fragile descemetocoele. Angiography can show venous non-perfusion and disrupted limbal arcades with neovascularization reaching the base of the gutter. Scleritis may be associated, whereas MU spares the sclera. Other findings in RA include keratoconjunctivitis sicca, episcleritis, and sclerosing keratitis [4].

Keratolysis is a disease of central corneal stromal disintegration that is often seen in patients with long-standing rheaumatoid arthritis. First, the central cornea swells and the epithelium begins to shed [1]. The disease process spreads until the corneal stroma is fully resorbed and a fragile Descemet’s membrane is left. This disease is generally painless.

Other collagen vascular diseases in which peripheral ulcerative keratitis can occur include systemic lupus erythematosus, systemic sclerosis, and relapsing polychondritis [4]. Peripheral ulcerative keratitis has also been reported to occur in association with inflammatory bowel disease, giant cell arteritis, staphylococcal marginal keratitis, HSV, and acanthamoeba keratitis.

Ocular involvement in Wegener’s granulomatosis can include proptosis, scleritis, and uveitis in addition to peripheral ulcerative keratitis. Polyarteritis nodosa can also cause choroidal or retinal vasculitis, scleritis, optic atrophy, papilledema, exudative retinal detachment, CRAO, and conjunctival lesions [4]. Wegener’s and polyarteritis nodosa can display severe leakage and neovascularization is seen from the tips of the limbal arcades. In Wegener’s, granulomas destroying limbal tissue can be seen in both the corneal and scleral side of the vascular changes [1].

Limbal involvement generally occurs in MU, whereas other forms of peripheral ulcerative keratitis usually spare the limbus [4]. The distribution of vascular involvement can differ when comparing MU to other causes of peripheral corneal ulceration. Mooren’s ulceration generally causes leakage from deep vascular networks that come from the long posterior ciliary circulation, with the unilateral form also blocking perfusion to the superficial network. In connective tissue disorders such as RA, angiography shows vaso-occlusion of capillary and venous circulation in the episcleral and conjunctival circulation [1]. In vascular disorders such as Wegener’s and polyarteritis nodosa, marked vascular leakage and granulomatous inflammation may be seen involving the episcleral and venous vessels.

Management

Wood and Kaufman noted that the two types of MU they described—one type being unilateral and developing in older patients, and the other type being bilateral in younger patient—respond differently to treatment. The first type tends to heal well after a conjunctival flap procedure or lamellar keratoplasty whereas the second type is not responsive to treatment.

Watson described three types of MU, described above under “Diagnosis”. While the unilateral from has been said to be readily treatable, other studies have suggested otherwise [1]. The suggested treatment for this form involves a trial of aggressive systemic and local immunotherapy (described below), followed by surgical removal of the corneal stroma up to Descemet’s membrane. Corneal transplant often fails due to recurrence of the disease or allograft rejection. Bilateral aggressive Mooren’s ulceration can also be treated with aggressive local and systemic immunosuppression. Bilateral indolent Mooren’s ulceration often resolves with dietary changes and treatment of any systemic infection that may be present. It can also be treated with local steroids and cyclosporine A [1].

Initial treatment of Mooren’s ulceration consists of topical corticosteroids. If corticosteroids do not control the inflammation, limbal conjunctival excision can be performed [19]. Excision of a 3-4 mm ring of limbal conjunctiva at least 2 clock hours adjacent to a MU has been shown to be an effective treatment. Studies have shown that when less than half of the limbus is involved, the cure rate after conjunctival excision and corneal ulcer resection is performed is 51.3% [2]. When more than half of the limbus is involved, the cure rate after the procedure decreases to 36.8%. In a 1975 study where limbal conjunctival excision was performed, 8 out of 10 eyes healed and one developed recurring ulcers which then healed upon re-treatment [20]. It was hypothesized that the limbal conjunctiva may contain antibodies that react with antigens in the corneal stroma in addition to enzymes that destroy the corneal stroma—therefore, excision may interrupt the disease process.

Surgical interventions can also include lamellar keratoplasty, keratoepithelioplasty, delimiting keratotomy, and conjunctival flap and patch grafts using periosteum or fascia lata [19]. Resection of the corneal lesion and adjacent conjunctiva combined with lamellar keratoplasty can achieve a final healing rate of 89.6%. If topical 1% cyclosporine A is added, a 95% final healing rate can be achieved [2].

Cryotherapy to the conjunctiva surrounding ulcers may temporarily halt the progression of the disease, but healing may not occur until the conjunctiva is excised [21]. Other potential local therapies include bandage contact lenses, tissue adhesive, subconjunctival heparin, and artificial tears and collagenase inhibitors [19]. Lecinthinated superoxide dismutase has also been found to be decrease epithelial defect size in patients with sterile corneal ulcers that do not respond to conventional therapy in some studies [22].

Systemic immunosuppression using cyclophosphamide, azathioprine, or methotrexate can be attempted if conjunctival resection yields no improvement [4],[19]. Interferon alpha-2b has been used in patients who had hepatitis C and concomitant Mooren’s ulceration. In more aggressive cases, oral corticosteroids, cyclosporine A, and methotrexate have also been used with some success [23].

A systematic review performed by Alhassan et al. found that there have not been any randomized controlled trials to compare the various treatment modalities for MU. The authors recommend that studies measuring outcomes such as percentage of area healed after treatment and speed of healing are necessary in order to ensure high quality care for these patients.

Complications

In addition to iritis being occasionally associated with Mooren’s ulceration, complications can include glaucoma, cataracts, and perforation [4]. Anterior uveitis occurs 6.8% of the time and can involve fine dusty keratic precipitates and posterior synechiae locally [2]. 2.3% develop complicated cataracts [2]. The rate of perforation has varied in different studies in various geographical locations. Perforation (figure 7) occurs most often in the limbal cornea, followed by the peripheral and then central cornea [2].
Figure 7     Perforated MU with iris herniation.  (Reproduced from Chen et al. [2] with permission from the British Journal of Ophthalmology.)
A study in South India described a perforation rate of 11% at the time of presentation [3]. This rate was higher for patients under 60 years old (27% vs 10%) and was more likely to occur in patients who had complete peripheral involvement of the corneal ulceration (73% of eyes with complete peripheral ulceration perforated, vs 20% of those with total peripheral ulceration and 6% of those with partial peripheral ulceration). Other studies of MU in South India described perforation rates varying from 0% [11] to 26% [9]. A study of 550 patients in China reported a perforation rate of 13% [2].

A Nigerian study suggested that, in addition to Mooren’s ulceration tending to affect more patients in their third and fourth decades of life, the perforation rate in these patients was more than one third [13]. This study was further supported by another study consisting of 9 patients from West Africa [14]. The authors of the latter study postulated that there were two distinct populations of patients with MU in Africa. The first population is older, more often develops unilateral disease, and responds to treatment whereas the second population is younger, tends to have bilateral disease which perforates more often and does not respond well to treatment. Further studies consisting of patients from the Republic of Zaire, Togo, and Sierra Leone further supported this hypothesis [3].

Another complication that often occurs is post-operative recurrence. Chen and colleagues described a recurrence rate of 25.6% of the time, which can occur between 2 weeks and 15 years postoperatively with 70.2% of recurrences occurring within 2-6 months. In recurrent cases, the first recurrence often occurs in the same location as the original ulcer and the interface of the donor graft and lamellar bed. Multiple recurrences, on the other hand, can occur in originally unaffected areas of the cornea suggesting a difference between the immunological mechanisms of initial and multiple recurrences [2].

Additional Resources

References

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