Progressive Multifocal Leukoencephalopathy (Grand Rounds)
Progressive Multifocal Leukoencephalopathy (PML)
To establish criterion for the diagnosis PML algorithm have been recommended.
Two approaches to establish the diagnosis of PML:
1. The presence of characteristic histopathological features of PML (triad of demyelination, enlarged oligodendroglial nuclei and bizarre astrocytes) with evidence of JC virus on electron microscopy, immunohistochemistry, or PCR
2. The presence of clinical features or classic radiographic criteria with a positive CSF JC virus PCR.
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Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A. PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section. Neurology. 2013 Apr 9;80(15):1430-8.