Progressive Multifocal Leukoencephalopathy (Grand Rounds)

From EyeWiki
Original article contributed by: Mona A. Kaleem, MD
All contributors: Nagham Al-Zubidi, MD
Assigned editor: Andrew Go Lee, MD
Review: Assigned status Up to Date by Nagham Al-Zubidi, MD on January 10, 2016.


Progressive Multifocal Leukoencephalopathy (PML)

Chief Complaint

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History

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Examination

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Anterior Segment

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Posterior Segment

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Neurological Examination

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Interim History

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MRI

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Inpatient Work-Up

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Differential Diagnosis

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Final Diagnosis

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To establish criterion for the diagnosis  PML algorithm have been recommended.

Two approaches to establish the diagnosis of PML:

1. The presence of characteristic histopathological features of PML (triad of demyelination, enlarged oligodendroglial nuclei and bizarre astrocytes) with evidence of JC virus on electron microscopy, immunohistochemistry, or PCR

Or

2. The presence of clinical features or classic radiographic criteria with a positive CSF JC virus PCR.

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Management

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Discussion

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References

MKSlide29.JPG Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A. PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section. Neurology. 2013 Apr 9;80(15):1430-8.

Bibliography

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Acknowledgements

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