Retinal Angiomatous Proliferation (RAP)

From EyeWiki

Disease Entity

Retinal Angiomatous Proliferation (RAP) was described by Yanuzzi and co-workers as a distinct form of neovascular Age-Related Degeneration (AMD).


Choroidal Neovascularization (CNV) in AMD originates from the choroid and can erode through the retinal pigment epithelium and communicate with the retinal circulation, resulting in a chorioretinal anastomosis.

RAP was described as neovascularization that starts at the retina and progresses posteriorly into sub retinal space. It was believed to eventually reach the choroidal circulation and form a retinal-choroidal anastomosis.

There has been some controversy on whether neovascularization arises from the retina or from the choroid. Yannuzzi et al stated in their last review that it is possible that angiogenesis starts in the retina, choroid or both, and they proposed an alternative name for this process: Type 3 neovascularization. This new designation would apply to neovessels within the retina and right underneath and it integrates with the classical neovascularization classification by Gass (Type 1 neovessels being located under the retinal pigment epithelium and Type 2 under the neurosensory retina). RAP remains however the most widely used denomination.


Several series have studied the prevalence of RAP, with estimates ranging from 10 to 21% of exudative AMD.


Patients with RAP tend to be older than patients with other forms of neovascular AMD (mean age of 79 vs 76, respectively). It is most common in white patients, uncommon in asian patients and not yet reported in black patients.


Three stages were originally described by Yanuzzi and co-workers:

Stage I: Intraretinal Neovascularization (IRN)

Vascular proliferation originates from the deep capillary plexus of the retina in the paramacular area and is confined within the retina, as a retinal-retinal anastomosis. Intraretinal haemorrhage and edema are common.

Stage II: Subretinal Neovascularization (SRN)

Neovascularization invades sub retinal space. Neurosensory and serous pigment epithelial detachment can be found, together with increasing edema of the retina and haemorrhages in the pre retinal and intraretinal spaces.

Stage III: Choroidal Neovascularization (CNV)

Choroidal neovascularization is present. It can associate vascularised pigment epithelial detachment. A retinal-choroidal anastomosis is formed.


Clinical diagnosis

The initial lesion is located extrafoveally, presumably because of lack of capillaries in the foveal avascular zone.

The presence of small macular haemorrhages, sometimes punctiform, often multiple, associated with oedema in an eye with soft drusen, is highly suggestive of RAP in its initial stages. Hemorrhages can be pre, intra or subretinal. Large subretinal hemorrage is rarely seen in stages I and II. As angiogenesis progresses, tortuous, dilated retinal vessels, sometimes showing retino-retinal anastomoses can be found.

Involvement is typically bilateral, with 80% of fellow eyes affected after 1 year and 100% before 3 years.

Diagnostic procedures

  • Fluorescein angiography: it can help in the diagnosis of early stage RAP lesions, but in later stages the dye stains the whole vascular-exudation complex and can be confused with occult CNV.
  • Indocyanine green angiography (ICG): RAP shows typically late-phase leakage of the ICG molecule into intraretinal spaces or cystoid edema. The ICG molecule has an affinity for fibrin, which is present in the cystic spaces.
  • OCT is useful in the initial stage of RAP to image the vessels and the cystic spaces within the retina. As the disease progresses and a serous or vascularized PED occurs, changes beneath the pigment epithelium become difficult to assess accurately. Sub–pigment epithelium blood, exudates, and neovascularization produce photoreflectance that can be indistinguishable.
  • New angio-OCT systems have the potential of becoming a very useful diagnostic tool for this disease.

Differential diagnosis

  • Idiopathic parafoveal telangiectasia is a condition involving dilation of retinal capillaries located near the fovea, in one or both eyes. Telangiectasias are not associated with serous PED, the RPE is healthier and choroidal neovascularization associated with parafoveal telangiectasias occurs less frequently.
  • Other forms of choroidal neovascularization (CNV) including polypoidal choroidal vasculopathy (PCV). Retinal haemorrhages in PCV are normally larger, with round reddish-orange macular lesions being observed in the eye fundus. Polyps can be seen in OCT as abrupt protrusions from the REP/Bruch’s membrane band, often associated with neurosensory detachment.


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