Corneal topography

From EyeWiki



History of Corneal topography

In early 17th century, Schiener used reflection of marbles from the cornea as perhaps the earliest corneal topography.[1] Placido’s disc was a major advancement in the late 19th century.[1][2] Placido disc has stood the test of time and the current placido based topographers work on the same principle of assessing the reflection of a concentric set of black and white rings from the convex anterior surface of the cornea. Recent advances in the technology use scanning slit methods for assessment of elevation data and incorporation of distortion free Scheimpflug photography techniques.

Uses

Corneal topography is most commonly used for the following purposes

  1. Refractive surgery: To screen candidates for normal corneal shape, patterns and ruling out suspicious or keratoconic patterns . Post operatively , topography can help to assess the dioptric change created at corneal level ( thus the effective change in the cornea) , ruling out decentred or incomplete ablation , post excimer ectasia or other changes.
  2. Keratoconus : Early screening of keratoconus suspects is one of the most useful roles of topography. Early keratoconus and suspects look normal on slit lamp examination ,and the central keratometry (3 mm) gives only a limited assessment. Therefore topography has become the gold standard in screening keratoconus suspects. In cases with established keratoconus, the role of topography is paramount for monitoring progression and doing a timely collagen cross linking , and in contact lens fitting.
  3. Post surgery astigmatism : Post cataract surgery and post keratoplasty corneal astigmatism can be studied with the topographer and selective suture removal or other interventions can be planned.
  4. Surgical planning in cases with astigmatism : Limbal relaxing incisions and other methods of topography guided incision placement are used by surgeons to reduce post operative astigmatism.
  5. Effect of corneal and ocular surface disorders: Disorders such as pterygium , limbal dermoid, localised corneal scars can cause a change in the corneal topography and thus the monitoring is very useful.
  6. Other uses : Contact lens fitting , incision placement and intrastromal ring placement in keratoconus , monitoring of ocular vs corneal wavefront.

General Principles

Corneal topography uses three of the following principles[3][4][5][6][7]

  1. Placido disc reflection
  2. Scanning slit
  3. Scheimpflug photography

Placido Disc Reflection for curvature analysis

The primary optical aim of cornea is refraction and focusing of the light rays as it acts as a covering lens overall. However , all non-ideal refracting surfaces reflect some light off them. This is the principle used for Purkinje imaging as well in the Placido discs. Placido disc is a device made of concentric rings drawn on a device of a different color (generally white rings on a black background) (Figure 1a).The first refracting surface of the cornea (more accurately , the tear film –air interface and not the epithelium) also acts as convex mirror and reflects back light in a pattern dependent of the corneal pattern (Figure 1b). Topographers use this technique to their advantage. Whereas the original placido discs were aimed a qualitative keratoscopy , the videokeratoscope or the topographer uses mathematical formulae to provide a point to point quantitative gradient of these subtle changes in topography.

Figure 1 a Placido Disc .JPGIllustrative placido.jpg

Scanning Slit elevation evaluation

It is one of the elevation based methods for assessment of topography. Multiple complimentary slits are used to perform an assessment of the corneal surface (Figure 2, left). In the Orbscan , 40 slits (20 each from nasal and temporal side) are projected on the cornea to assess 240 points on each slit. The triangulation between the reference slit beam surface and the reflected beam captured by the camera can be used to analyse the anterior and posterior corneal curvature and the pachymetry (Figure 2, right).

Scanning Slit and concept of triangulation

Scheimpflug principle based assessment

The non planar shape of cornea can potentially lead to spurious results and therefore the use of schiempflug principle in corneal imaging is a welcome new change. Theodre Scheimpflug , an Austrian army man worked extensively on a method for correcting arial skew distortion in perspective photographs.[7][8] Even though the technique was described before him, his development of the principle let his name to be associated with the principle. In an ideal scenario , the lens plane and the image plane are parallel. Therefore a linear object will form a plane of focus parallel to the lens plane and thus can be focused totally on the image plane (Figure 3a). Consider a situation , when the object is not parallel to the prospective image plane .It will not be possible to focus all the image on a plane parallel to image plane (Figure 3b). Thus this may lead to image distortion. However, according to the Scheimpflug principle, when a planar subject is not parallel to the image plane , an oblique tangent can be drawn from the image, object and lens planes, and the point of intersection is called schiempflug intersection (Figure 3c) .Using this orientation, A careful manipulation of the image plane and the lens plane can however lead to a focused and sharp image on the non parallel object.

Scheimp4aGPrakash.JPG

Scheimp4bGPrakash.JPG

Figure 4c ScheimpGPrakash.jpg

Interpretation of a topography printout

A modern topography printout can be quite daunting for the beginner because of the volumes of data it contains. This is a major shift from the rather simplistic videokeratographs and keratometers.

A stepwise approach is very handy in interpretation.

Step 1. Correctly identify the patient, age and eye.

Step 2 . Start by looking at the quad or multi map option as it gives the best visual comparison of the data. Below are the multimap (4x) options in the Orbscan (Bausch and Lomb, NY) topographer which is placido and scanning slit based and the Sirrus (CSO, Italy) topographer which is Placido and Scheimpflug based.

Figure 4 a : Normal Orbscan Quad MapNormal Scheimpflug GPrakash.jpg

Step 3. Next step is to look at the pseudocolor scale and identify the range and gradient of the values given. Each scan will have a color coding scale for the indices measured. For the absolute topographic map, these will the absolute dioptric value at that point of the cornea. As we are trained to look at patterns for keratoconus or other corneal abnormalities, a tighter color coding scale may enhance patterns or more lax color coding scale will lead to missing out patterns.

The figure 5 given below illustrates the importance of reading the grading scale and using a fixed dioptric scale which is specific for a given range.A patient witheratometric values of K1 38.5D/K2 39.5D is used as an example.As the tightness of the dioptric steps is decreased and overall range of dioptric steps in increased , the details are lost and a suspicious pattern could be overlooked. To avoid this error , most topographers use a small zone of absolute scale at a fixed interval of 0.5 D ,adjusting the greenish colors to near-normal values . However , this is customizable and thus same scale should be used when comparing scans.

Idesign topo scans GPrakash.jpg


Step 4. On an absolute scale, the green colors are most representative of normative data and thus a quick review of the scan will help. Too much red is almost always abnormal. The scan should now be mentally compared to patterns seen in keratoconus or other suspected corneal disorder. A classical pattern may be picked up easily , however more experience is required for atypical patterns.

Analysis techniques slide GPrakash.jpg

With practice, one can identify patterns quickly. For example , the figure below shows common patterns seen in keratoconus patients

Keratoconus patterns GPrakash.jpg


Step 5. The next step is to look at the actual numbers on the charts and in the statistics boxes.Numerical overlays show thinning and central corneal thickness , apical keratometry , anterior and posterior corneal elevations and specific details at a point , which can be assessed by moving the cursor on that point.The figure below shows the important numerical overlays in a Scheimpflug topography printout.

Numerical overlays and stats box GPrakash.jpg


Statistics box: Useful data on SimK, minimum corneal thickness , 3,5,7 mm zone irregularity , kappa angle , pupil diameter and white to white diameter can be seen in these charts. The figure below shows the statistics box in an Orbscan topographer printout.

Normal orbscan statistics box GPrakash.jpg

Step 6 . Compare with slit lamp findings again. It should always be kept in mind that corneal topography can be effected by corneal artifacts and therefore interpretative value is decreased in cases such as nebulomacular corneal opacities, dry eye , corneal neovascularisations and corneal scars.

Case examples

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Case examples topography GPrakash (2).JPG

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Case examples topography GPrakash (5).JPG

Case examples topography GPrakash (6).JPG

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Case examples topography GPrakash (8).JPG\

Case examples topography GPrakash (9).JPG

Case examples topography GPrakash (10).JPG


Additional Resources

References

  1. 1.0 1.1 Gatinel D., Corneal Topography and Wave Front Analysis :In Albert & Jakobiec's Principles & Practice of Ophthalmology (Chapter 70, Section History of corneal topography) Retrived from http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&eid=4-u1.0-B978-1-4160-0016-7..50073-4--cesec3&isbn=9781416000167&decorator=none&type=bookPage#lpState=open&lpTab=contentsTab&content=4-u1.0-B978-1-4160-0016-7..50073-4--cesec3%3Bfrom%3Dtoc%3Btype%3DbookPage%3Bisbn%3D978-1-4160-0016-7&search=none , accessed  on 22.03.2014
  2. Placido A: Novo instrumento per analyse immediate das irregularitades de curvatura da cornea. Periodico Oftalmol Practica 1880; 6:44-49.
  3. Swartz T, Marten L, Wang M. Measuring the cornea: the latest developments in corneal topography. Curr Opin Ophthalmol. 2007 ;18(4):325-33.
  4. Oliveira CM, Ribeiro C, Franco S. Corneal imaging with slit-scanning and Scheimpflug imaging techniques. Clin Exp Optom. 2011;94(1):33-42.
  5. Piñero DP, Nieto JC, Lopez-Miguel A. Characterization of corneal structure in keratoconus. J Cataract Refract Surg. 2012 ;38(12):2167-83.
  6. Wegener A, Laser-Junga H. Photography of the anterior eye segment according to Scheimpflug's principle: options and limitations - a review. Clin Experiment
    Ophthalmol. 2009;37(1):144-54.
  7. 7.0 7.1 Merklinger HM. The Scheimpflug Principle—Part I . Accessed online from http://www.trenholm.org/hmmerk/SHBG05.pdf . Accessed on 22.03.14
  8. [multiple authors] .Scheimpflug principle. Accessed online from http://en.wikipedia.org/wiki/Scheimpflug_principle . Accessed on 22.03.14