Cataract

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A cataract is a clouding of the natural intraocular crystalline lens that focuses the light entering the eye onto the retina. This cloudiness can cause a decrease in vision and may lead to eventual blindness if left untreated. Cataracts often develop slowly and painlessly, so vision and lifestyle can be affected without a person realizing it. Worldwide, cataracts are the number one cause of preventable blindness. There is no medical treatment to prevent the development or progression of cataracts. Modern cataract surgery, which is the removal of the cloudy lens and implantation of a clear intraocular lens (IOL), is the only accepted treatment for cataracts. Cataract surgery is the most effective and most common procedure performed in all of medicine with 3 million Americans choosing to have cataract surgery each year, with an overall success rate of 97 percent or higher.

Cataracts often develop slowly with a gradual decline in vision that cannot be corrected with glasses. Common complaints include blurry vision, difficulty reading in dim light, poor vision at night, glare and halos around lights, and occasionally double vision. Other signs of cataracts include frequent changes in the prescription of glasses and a new ability to read without reading glasses in patients over 55.


There are several types of cataract including age related, traumatic, and metabolic. Age related is the most common type and the pathogenesis is multifactorial and not fully understood. A traumatic cataract can occur following both blunt and penetrating eye injuries as well as after electrocution, chemical burns, and exposure to radiation. Metabolic cataracts occur in uncontrolled diabetics, patients with galactosemia, Wilson disease, and Myotonic dystrophy.


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Contents

Disease Entity

Cataract 366.xx

366.00 Nonsenile cataract unspecified
366.01 Anterior subcapsular polar nonsenile cataract
366.02 Posterior subcapsular polar nonsenile cataract
366.03 Cortical lamellar or zonular nonsenile cataract
366.04 Nuclear nonsenile cataract

366.09 Other and combined forms of nonsenile cataract

366.10 Senile cataract unspecified
366.11 Pseudoexfoliation of lens capsule
366.12 Incipient senile cataract
366.13 Anterior subcapsular polar senile cataract
366.14 Posterior subcapsular polar senile cataract
366.15 Cortical senile cataract
366.16 Senile nuclear sclerosis
366.17 Total or mature cataract
366.18 Hypermature cataract
366.19 Other and combined forms of senile cataract
366.2 Traumatic cataract
366.20 Traumatic cataract unspecified
366.21 Localized traumatic opacities
366.22 Total traumatic cataract
366.23 Partially resolved traumatic cataract
366.3 Cataract secondary to ocular disorders
366.30 Cataract complication unspecified
366.31 Cataract secondary to glaucomatous flecks (subcapsular)
366.32 Cataract in inflammatory ocular disorders
366.33 Cataract with ocular neovascularization
366.34 Cataract in degenerative ocular disorders
366.4 Cataract associated with other disorders
366.41 Diabetic cataract

366.42 Tetanic cataract
366.43 Myotonic cataract
366.44 Cataract associated with other syndromes
366.45 Toxic cataract
366.46 Cataract associated with radiation and other physical influences

Disease

While the majority of cataracts in the population are age-related, or senile, cataracts, there are many types and causes of cataract. This article will discuss the three most common types of cataracts (nuclear, cortical, and posterior subcapsular) as well as other less common types including anterior subcapsular, posterior polar, traumatic, congenital and polychromatic.

 

In age-related cataract, the pathogenesis of cataract development is multifactorial and includes the following factors[1]:

  • Compaction and stiffening of the central lens material (nuclear sclerosis) as new layers of cortical (outer lens) fibers continue to proliferate over time
  • Abnormal changes in lens proteins (crystallins) resulting in their chemical and structural alteration, leading to loss of transparency
  • Pigmentation of lens proteins (yellow-->brown)
  • Changes in the ionic components of the lens


Symptoms

A cataract is defined as any opacification of the eye's crystalline lens, and any of these changes that then lead to a degradation in the optical quality of the lens can cause visual symptoms. As there are a wide variety of cataract types, there is a large spectrum of visual symptoms associated with cataractous changes. [2]


These symptoms may include:

  • Blurred vision at distance or near (different types may affect distance greater than near or vice versa, see below)
  • Glare (halos or streaks around lights, difficulty seeing in the presence of bright lights)
  • Difficulty seeing in low light situations (including poor night vision)
  • Loss of contrast sensitivity
  • Loss of ability to discern colors
  • Increasing near-sightedness or change in refractive status (including "second sight" phenomenon)


Risk Factors

Risk factors for cataract development include the following:

  • Diabetes or elevated blood sugar
  • Steroid use (oral, IV, or inhaled)
  • Ultraviolet exposure
  • Smoking
  • Ocular diseases: Retinitis Pigmentosa, Uveitis, 
  • Ocular Trauma
  • Prior ocular surgery
  • Genetic predisposition

 

Common Types of Cataracts

Age related is by far the most common type of cataract and it is divided into 3 types based on the anatomy of the human lens. There are Nuclear Sclerotic, Cortical and Posterior Subcapsular Cataracts. Patients commonly develop opacity in more than one area of their lens which can cause overlap in the classification of cataracts.

Nuclear Sclerotic

Etiology

Nuclear sclerosis is the yellowing and hardening of the central portion of the crystalline lens and it occurs slowly over years. As the core of the lens hardens, it often causes the lens to increase the refractive power and causes nearsightedness. This is why some patients who had previously relied on reading glasses for reading may no longer need them once a nuclear sclerotic cataract starts to form. This type of cataract can also cause colors to be less vibrant although the change is so gradual that it is often not noticed.

Symptoms

  • Blurring of distance more than near vision (typically, but others may notice worsening of reading more than distance)
  • Increasing myopia ("Second-sight" phenomenon of improved uncorrected distance vision in hyperopes and improved uncorrected near vision in emetropes)
  • Poor vision in dark settings such as night driving
  • Decreased contrast and decreased ability to discern colors
  • Glare
  • Monocular diplopia

Cortical

Etiology

Cortical cataracts occur when the portion of lens fibers surrounding the nucleus become opacified. The impact on vision is related to how close the opacities are to the center of the visual axis and their impact can vary greatly. Progression is variable with some progressing over years and others in months. The most common symptom from cortical cataracts is glare, especially from headlights while night driving.

Symptoms

  • Glare is often the predominate symptoms
  • Decreased distance and near vision
  • Decreased contrast sensitivity

Posterior Subcapsular

Etiology

Posterior subcapsular cataracts (PSC) are opacities located in the most posterior cortical layer, directly under the lens capsule. This type of cataract tends to occur in younger patients than cortical or nuclear sclerotic cataracts. Progression is variable but tends to occur more rapidly than in nuclear sclerosis. Symptoms are glare, difficulty seeing in bright light, and near vision is often more affected than distance.

Symptoms

  • Glare
  • Difficulty with near greater than distance vision (typically, but many patients may notice the opposite)
  • Often rapidly diminishing vision

Other Types of Cataract


Anterior Subcapsular

Etiology

Anterior subcapsular cataracts can develop idiopathically, may be secondary to trauma, or may be iatrogenic. Phakic intraocular lenses used to correct refractive error, such as the Visian implantable collamer lens (ICL), have been reported to cause anterior subcapsular cataracts due to ICL-lens touch from inadequate vaulting of the ICL.


Posterior Polar

Posterior polar cataracts are characterized by well-demarcated white opacities in the center of the posterior capsule. These opacities often project forward as cylinders penetrating into the posterior lens cortex. 

Etiology

Posterior polar cataracts are typically congenital and autosomal dominantly inherited. 

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Symptoms

Most posterior polar cataracts are asymptomatic or minimally symptomatic. However, over time posterior subcapsular (PSC) opacities may form around the posterior polar opacity. As the PSC progresses, vision may be severely affected.


Posterior polar cataracts pose a unique challenge for cataract surgery. The rate of posterior capsular rupture is significantly higher in these cases. The posterior capsule is weakened around the posterior polar opacity and in some cases there may even be a defect in the capsule. 

Traumatic Cataract

A traumatic cataract develops to the effected eye after an incident.

Etiology

A traumatic cataract can occur following both blunt and penetrating eye injuries as well as after electrocution, chemical burns, and exposure to radiation

Symptoms

The clouding of the lens at the site of injury which could extends to the whole lens. The development could be quick after the incident.

Congenital Cataract

Etiology

Congenital cataracts may occur as unilateral or bilateral isolated findings or may be associated with systemic disease. Most cases associated with systemic diseases are bilateral. Approximately 1 in every 250 children in the United States is born with a congenital cataract (defined as some lens opacity present at birth), but many are subclinical.


In general:

--1/3 are associated with systemic disease

--1/3 are inherited traits

--1/3 are of undetermined cause









Polychromatic

Etiology

Also known as a "Christmas Tree" cataract, these consist of highly reflective, iridescent corneal crystals of various colors. They may be seen as a rare variant of senile cataractous development and they are also found with a higher prevalence in patients with myotonic dystrophy.

Diagnostic Testing

When patients are evaluated for cataracts, the primary objective is to determine the following:

1) is there is a visually significant lens opacity;
2) does the lens opacity account for the patients level of vision;
3) would removal of the cataract likely lead to improved vision and improved level of functioning and is the potential improvement enough to warrant the risks of surgery;
4) would the patient tolerate the operation and be able to follow postoperative instructions and follow up care.

If the answers to these questions lead the patient and physcian to agree that surgical intervention is warranted, preoperative planning must be done.

Ophthalmic Examination

Visual function is determined by asking the patient how they are limited in function by their vision and by measuring their visual acuity with and without spectacle correction. In patients complaining of glare, brightness acuity is tested by asking a patient to read the eye chart while shining a bright light at the patient from the side. There are also other instruments which can mimic glare. These simulate the oncoming headlights of night driving and can reveal functional impairment. A comprehensive dilated eye exam is performed on all patients when possible. Specific attention is paid to several factors impacting surgical planning including the severity of the cataract, the size of the dilated pupil (smaller pupils increase the complication rate), the clarity, thickness and health of the cornea, stability of the lens, depth of the anterior chamber, and health of the optic nerve and retina.

Preoperative Measurements

In order to get the best possible visual outcomes, several preoperative measurements are necessary to determine the power of the IOL implant. A careful refraction of both eyes, especially if planning on operating on only one eye, is needed to avoid dissimilar refractive errors postoperatively, as this can be disturbing to patients. To determine the IOL power needed, measurements of the axial length of the eye, the corneal refractive power, and the anterior chamber depth are taken. Additional tests that can be helpful in select cases include corneal topography and endothelial cell counts.

Management


Nonsurgical Treatment

No medical treatment has been show to be effective in the treatment or prevention of cataracts, although this is an active area of research. To slow the development of cataracts it is generally recommended that patients eat a balanced diet, prevent excessive exposure to UV radiation by using good quality UV blocking sunglasses, avoiding injuries by using protective eyewear, and if diabetic closely control blood sugar levels.
Other approaches to temporarily improve visual function include careful refraction to get the best-corrected vision, pharmacological dilation, increased lighting and the use of magnifiers for near work.

Surgical Treatment

Cataract surgery is one of the most common surgical procedures performed around the world and has a very high success rate. The most common type of cataract surgery in the United States utilizes ultrasound energy to break the cataract into particles small enough to aspirate through a handpiece. This technique is referred to as phacoemulsification. Other techniques include manual extracapsular cataract extraction (ECCE) in which the entire nucleus of the cataract is removed from the eye in one piece after extracting it from the capsular bag. While ECCE traditionally involved a large incision that required multiple sutures, a newer techinique known by many names (such as manual small incision cataract surgery or small incision ECCE) allows for manual extraction without the need for any sutures. 


The goal in modern cataract surgery is not only the removal of the cataract, but also the replacement of the cataract with an intraocular lens (IOL). The IOL is typically placed during the cataract surgery, and may be placed in the capsular bag as a posterior chamber lens (PCIOL), in the ciliary sulcus, as a sulcus lens, or in the anterior chamber anterior to the iris as an anterior chamber lens (ACIOL). There are multiple types of IOLs that may be used in modern cataract surgery, including monofocal, multifocal, accomodative, and astigmatism-correcting lenses. The goal of all IOLs is to improve vision and limit dependency upon spectacles or contact lenses. 


Recently, the femtosecond laser, familiar to the refractive ophthalmologist for its role in LASIK, INTACS, and corneal transplantation, has been adapted to assist in cataract surgery. This procedure still relies upon the cataract surgeon to remove lens material in a manner similar to phacoemulsification, but it replaces several manual steps of the procedure with a more automated laser mechanism.   


Additional Resources

Basic Clinical Science Course of the American Academy of Ophthalmology. Section 11. 2011 - 2012. Purchase/View here 

Cataract in the Adult Eye: Surgery and Diagnostic Procedures. Preferred Practice Patterns.American Academy of Ophthalmology. September 2006. Purchase/View here

Plager D, Carter C. Pediatric Cataract. Focal Points. American Academy of Ophthalmology. February 2011. Purchase here

References

  1. Basic Clinical Science Course (BCSC) of the American Academy of Ophthalmology. Section 11. 2006 - 2007.
  2. Cataract in the Adult Eye: Surgery and Diagnostic Procedures. Preferred Practice Patterns.American Academy of Ophthalmology. September 2006. Purchase/View here
Original article contributed by: Brad H. Feldman, M.D., Sebastian Heersink, MD
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