File:Screenshot 2025-12-21 at 7.42.11 PM.png
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The mechanism of action of JAK inhibitors adapted from Shawky, Ahmed M, et al. Janus kinase (JAK) inhibitors block the kinase domain of cytoplasmic non-receptor tyrosine kinases (JAKs), preventing the phosphorylation of STAT transcription factors. By disrupting the JAK-STAT pathway, they reduce cytokine-mediated signal transduction that drives inflammatory and autoimmune responses. This inhibition interferes with the pathogenic immune activation pathway, which promotes inflammation, immune response, and cancer.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 19:51, December 21, 2025 | | 2,194 × 1,252 (1.14 MB) | Rona.Z.Silkiss (talk | contribs) |
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