- 1 Disease Entity
- 2 Diagnosis
- 3 Differential diagnosis with defining features
- 4 Laboratory test
- 5 Management
- 6 References
Choroideremia is recognized by the following codes as per the International Classification of Diseases (ICD) nomenclature:
OMIM Entry # 303100
Choroideremia is an X-linked chorioretinal dystrophy characterized by the diffuse, progressive degeneration of the retinal pigment epithelium (RPE), photoreceptors and choriocapillaris. It is caused by a mutation in the CHM gene and is the focus of exciting basic and clinical research. Gene therapy through viral vectors has shown early promise in the possible treatment of this blinding disease.
Choroideremia was first described in 1872 by Ludwig Mauthnuer, an Austrian ophthalmologist. Initially, it was thought to be a developmental anomaly, similar to a choroidal coloboma, due to the near total lack of choroidal vessels. Upon observation of less extreme cases, the progressive nature of the disease became apparent. An X-linked connection was proposed in 1942, but it wasn’t until 1990 that the specific gene was cloned.  The CHM gene was one of the first genes to be identified by positional cloning and was one of the first genes to be established as a cause of an inherited retinal degeneration. Since the early 1990s, over 106 pathogenic variations in the CHM gene have been discovered. The most exciting developments have happened in the last several years, with the development of viral vectors designed to replace the mutated CHM gene.
Choroideremia derives its name from the almost complete loss of retina, choroid and RPE that leads to exposure of the underlying white sclera. It is derived from “choroideremie”, which is thought to be a combination of the ancient Greek word “eremia,” meaning barren land or dessert, and “chorion”, which is ancient Greek for skin.
Choroideremia is a rare chorioretinal dystrophy that is estimated to affect between 1 in 50,000 to 1 in 100,000 individuals. Men are predominantly affected due to its X-linked etiology, but women can be asymptomatic carriers or rarely can be affected by the dystrophy as well. Northern Finland has the highest reported prevalence. There are thought to be more than 500 affected males in the United Kingdom and around 3000 throughout Europe.
Choroideremia is due to various mutations involving the CHM gene, which is located on chromosome Xq21.2, and is inherited in an X-linked recessive manner. The gene spans 186,382 bp and the mRNA is made up of 15 exons and is 5442 bp long. The open reading frame is 1,962 bp and produces a 653 amino acid long protein (95 kDa). One hundred and six pathogenic variants in the CHM gene have been identified.  A variety of mutations have been discovered involving the CHM gene, including deletions, insertions, duplications, translocations, nonsense, splice-site, frameshift and missense mutations.
Physiology and Pathology
The CHM gene encodes for Rab escort protein-1 (REP-1). REP-1 is one of two Rab escort proteins, both of which are found throughout the body. REP-1 is involved in a complex system of intracellular trafficking of various lipid membrane-bound structures. These vesicular structures are guided by GTP-binding proteins (Rab proteins). For Rab proteins to be connected to the lipid membrane and allow intracellular trafficking, they need to be prenylated, which is the addition of geranylgeranyl groups to a molecule. REP-1 proteins aid in this process by bringing Rab proteins to the Rab geranylgeranyltransferase (GGTase) complex, where the prenylation occurs. REP-1 also facilitates the transfer of the prenylated Rab protein to its target location. Without this escort, the prenylated Rab would undergo inactivation. The figure to the left demonstrates the role of REP in the Rab cycle. 
Mutations in the CHM gene create defects in REP-1. This leads to improper intracellular vesicular trafficking and is thought to impair the transport of proteins from the Golgi apparatus to the outer segments in photoreceptors, as well as the impairment of phagocytosis and degradation of shed outer segments by RPE cells.
Multiple types of mutations of the CHM gene have been described, but no particular type of mutation has been associated with a worse or better prognosis. This lack in phenotypic variability is not entirely surprising in that most mutations described show a near universal lack of REP-1 protein expression. Variations in severity of disease must be due to factors other than the underlying mutation.
The specific anatomic location of the initial pathologic degeneration remains controversial. Some studies have suggested that the primary pathology in choroideremia resides in the RPE followed by degeneration of the photoreceptor layer and choroid. Others have suggested the primary pathology develops in the photoreceptors, with subsequent loss of the RPE and choriocapillaris. Finally, other examinations have suggested an independent loss of photoreceptors and RPE followed by degeneration of the choroid. A recent histopathologic study found an inflammatory component to the disease process along with prominent gliosis, with gliosis likely being a secondary event.
Choroideremia becomes symptomatic during the first decade of childhood with the development of nyctalopia. It then progresses to peripheral vision loss in teenage years with sparing of central vision and maintenance of good visual acuity until the fifth to seventh decade of life. At around the fifth decade of life, most patients develop a rapid deterioration in central vision. Color vision is lost as degeneration of the macula takes place, and can occur prior to loss of visual acuity. Phenotypic variation within a family can be striking, with some affected males significantly less affected than other males. Carriers, for the most part, are asymptomatic and even when female carriers are symptomatic their disease is less severe than their male offspring.
On fundus examination, the earliest manifestation is widespread pigment clumping at the level of the RPE, which is distinct from the characteristic perivascular bone-spicule pigment clumping seen in retinitis pigmentosa. Subsequently, patients develop well-defined regions of atrophy with visible underlying sclera and large choroidal vessels, most commonly in the postequatorial region just outside the vascular arcades. These areas of atrophy advance centripetally and are also found in a peripapillary and parapapillary manner (See image below). An island of foveal tissue may persist until later stages of the disease when central and color vision become affected from foveal atrophy. Patients have preserved larger choroidal blood vessels and normal appearing retinal vessels. In addition, choroideremia exhibits no optic atrophy, unlike the waxy pallor of optic discs seen in retinitis pigmentosa. Carrier patients can have mild RPE changes, and in severe cases, patchy RPE degeneration and areas of atrophy. This phenotypic variability in carriers is due to lyonization in which one copy of the X chromosome is randomly silenced early in embryogenesis. Other associated ocular findings include 31% of patients developing posterior subcapsular cataracts and a small risk of macular edema or choroidal neovascularization.
Fluorescein angiographyOn fluorescein angiography, scalloped areas of missing choriocapillaris appear hypofluorescent next to brightly hyperfluorescent areas of perfused choriocapillaris (See image below). Although not a common feature, choroidal neovascularization secondary to choroideremia can develop, leading to leakage characteristic of neovascularization.
Fundus autofluorescence can show early loss of peripheral autofluorescence with subsequent centripetal loss. The scalloped edges of demarcation are sharp and can clarify areas of the fundus that are affected and not apparent on fundus examination (See images below). Hypoautofluorescence in the nonatrophic areas may precede photoreceptor cell death, and the amount of hypoautofluorescence may help predict disease activity and help identify patients undergoing a more rapid degeneration. A speckled autofluorescence may be observed in an otherwise unaffected macula in both affected males and carriers.
Electroretinography is abnormal early in the course of the disease, with a reduced scotopic component before the photopic component. It becomes extinguished by midlife. Carriers generally have a normal ERG pattern but symptomatic carriers may develop minor changes, in particular a subnormal 30-Hz flicker response on full-field ERG or diffuse elevation of 650-nm dark-adapted thresholds.
Optical Coherence Tomography
Optical coherence tomography demonstrates preservation of the inner retinal layers throughout the disease process. Patients tend to have a small increase in central retinal thickness early in the course of disease when normal visual acuity is present, but eventually develop progressive subfoveal retinal thinning as visual acuity declines. OCT can demonstrate a reduction in subfoveal choroidal thickness. As the disease progresses, patients often develop retinal tubulations in the outer nuclear layers and inner retinal microcysts.  One study showed that 62.5 % of patients showed some degree of cystoid macular edema on OCT.
Visual field loss is consistent with the location of chorioretinal degeneration. The earliest field change is a patchy loss of midperipheral vision. Progressive, patchy atrophy can lead to irregular scotomas and eventually to near complete loss of a central and peripheral vision. In advanced disease small islands of vision can remain in the fovea and light can be perceived in the far periphery.
OCT angiography is a noninvase, functional extension of OCT for visualizing retinal and choroidal microvasculature. Advanced cases of choroideremia can result in the distortion of the neurosensory retina, RPE and choriocapillaris, which can complicate the interpretation of both FA and OCT. Patel et al demonstrated the use of OCT angiography in the characterization and quantification of CNV in a patient with choroideremia. More research is necessary to clarify the role of this new technology in the management of choroideremia.
Differential diagnosis with defining features
- Gyrate atrophy: Choroidetemia in early stages may mimic gyrate atrophy of retina and choroid. Examination of fundus of family members, early presentation, and X-linked inheritance pattern are important features to clinically differentiate choroideremia from gyrate atrophy. Autosomal recessive, well demarcated scalloped areas of chorioretinal atrophy, nyctalopia in second to third decade, systemic hyperornithinemia, myopia and early cataracts
- Retinitis Pigmentosa: Waxy disc pallor, peripheral RPE bone spicule like degeneration, retinal arteriolar attenuation
- Myopic Degeneration: Absence of nyctalopia, tessellated fundus, lacquer cracks, diffuse atrophy, patchy atrophy, posterior staphyloma, high axial length, macular atrophy, straightened and stretched vessels, high rates of choroidal neovascularization, temporal peripapillary atrophic crescent, hemorrhages and tilting of the optic disc
- Ocular albinism: Infantile nystagmus, iris translucency, substantial hypopigmentation of ocular fundus, foveal hypoplasia, aberrant optic pathway projection associated with asymmetry of cortical responses on visual evoked potential testing
- Usher syndrome type 1: Autosomal recessive, pigmentary retinopathy, congenital deafness, imbalance from vestibular dysfunction
- Thioridazine hydrochloride retinal toxicity: History of medication use, loss of night vision, decreased ERG amplitudes, accumulation of fine or coarse pigment clumps, geographic RPE and choriocapillary atrophy
- Bietti crystalline dystrophy: Autosomal recessive, corneal deposits, yellow-white crystalline retinal deposits, progressive atrophy of the RPE, loss of choriocapillaris, progressive nyctalopia, visual field constriction, legal blindness in the fifth or sixth decades of life
The diagnosis of choroideremia can be suggested by characteristic fundus findings and family history. It can be confirmed by direct genetic testing or through immunoblot analysis with anti-REP-1 antibody. Confirmation is warranted due to phenotypic variation and clinical overlap with other conditions, with possible therapeutic and prognostic relevance if an alternative diagnosis is made.
Gene delivery through the Adeno-Associated Virus Subtype 2 Viral Vector
Recent success in the treatment of Leber’s congenital amaurosis has brought hope to developing a successful therapy for choroideremia. Since choroideremia is a genetic disease and caused by a mutation of one gene, it is a promising candidate for successful gene therapy. 
Recent investigational therapies have focused on replacing the defective gene via viral vectors. Adeno-associated virus subtype 2 (AAV2) has been of particular interest in ophthalmic research due to its affinity for primate photoreceptors and RPE. This subtype of adeno-associated viruses also has the advantage of being well characterized in a number of animal models. The amount of genetic material that can be transmitted by a virus is limited by the packaging capacity of the vector, so the size of the gene to be replaced is important. The limit of AAV vectors is estimated to around 5kb for single stranded DNA, which is much greater than the approximate 1.9kb coding sequence of REP-1.
Prior to the investigational treatment in humans, the replacement of the REP-1 gene was first investigated in mice. REP-1 replacement via the AAV2 vector was demonstrated to be feasible by Tamolchova et al. In addition, they demonstrated an improvement in ERG responses in mice following subretinal injections of the designed viral vector.
In a recent, multicenter phase 1/2 clinical trial, six male patients were administered with AAV.REP1. The surgical techinques and results are discussed below.
The viral vectors in this study were placed subretinally. The first step in the surgical procedure was to detach the target retina with the use of balanced salt solution injected through a 41G Teflon cannula. Once detached, a fixed volume (0.1mL) of 1×1010 AAV2.REP1 genome particles was injected into the subretinal space in 5 of 6 patients. In the sixth patient, a dose of 6×109 was injected. The injection of viral particles resulted in extension of the detachment in all patients. The sixth patient was injected with a smaller dose of viral particles because of difficulty in creating a detachment in that patient and concern about stretching the papillomacular bundle.
At six months, the mean change in ETDRS letters was +3.8 letters in the treated eyes in comparison to +1.5 letters in the control eyes. Statistical analysis was not published in this study due to small sample size. Patient 1 had a +21 letter improvement and patient 4 had a +11 letter improvement, with the other patients have a marginal loss in visual acuity. On microperimetry, a mean increase was noted in retinal sensitivity with respect to the dimmest stimulus seen, mean retinal sensitivity and total number of test points seen, in contrast to a reduction in all of these parameters in the patient's contralateral eye. In regards to safety, there was no observed immune response to the injected viral particles. Two patients had mild distortion of central vision which resolved by 6 months. All patients had sub-clinical progression of lens opacification, as expected following vitrectomy. No serious systemic or ocular adverse events were reported.
At 3.5 years, the patients who had initial improvement in visual acuity maintained that visual acuity. Three other patients did not have a significant change in visual acuity and one patient had a decline in vision. The patient who had a decline in vision was the patient injected with a lower total vector dose.
These studies are promising because they show the feasibility and tolerability of gene therapy through a viral vector in humans with choroideremia. More studies will be needed to investigate further clarify the effectiveness and safety of this therapy.
Current Viral Vector Studies
Here is a global list of clinical trials into the treatment of choroideremia through viral vectors:
Lutein has been investigated as a supplement to reduce the progression of atrophy and vision loss in choroideremia. Lutein is a carotenoid that is present in high concentrations in the macula. It works as a filter protecting the macula from blue light and functions as a free radical scavenger and antioxidant. Supplementation with oral lutein (20 mg per day) has been investigated over a 6 month period. Results demonstrated an increase in serum lutein and macular pigment levels, but absolute foveal sensitivity did not change, suggesting no short term benefit from supplementation. No studies looking into the long-term effectiveness of oral lutein supplementation have been conducted.
Frank macular edema is not a typical feature of choroideremia, but its development may result in a sudden decline in central visual acuity. The pathogenic etiology of macular edema in patients with retinal dystrophies remains poorly understood. It may be treated with topical dorzolamide, which was demonstrated to be effective in a small study. This therapy is similar to the management of macular edema found in other retinal dystrophies such as retinitis pigmentosa. While the edema may be responsive to anti-VEGF agents as demonstrated in retinitis pigmentosa patients, it may be more appropriate to begin with topical carbonic anhydrase inhibitor therapy and if that fails then move to more invasive options.
Surgeons may be appropriately concerned about performing cataract surgery in patients with choroideremia. Patients are placed at risk of phototoxicity from microscope illumination as well as at risk of postoperative pseudophakic macular edema. Few studies have been performed looking at outcomes of cataract surgery in this patient population. One study, a case series of 6 patients, demonstrated an improvement in visual acuity with cataract surgery without the development of postoperative macular edema. Two patients did develop early capsular phimosis however, suggesting this may be a feature of the disease.  When performing cataract surgery in patients with choroideremia, it is important to obtain appropriate informed consent and educating patients about the potential risks of the procedure and the unknowns of the post-operative course.
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