Dacryops, also known as lacrimal gland cyst or lacrimal duct cyst, was described more than 200 years ago. It is an uncommon but benign condition characterized by a fluid-filled cyst in association with normal lacrimal tissue. The lacrimal gland ("simple dacryops") is by far the most common anatomical site, but any lacrimal tissue, including the accessory lacrimal glands and ectopic lacrimal tissue, can produce these cysts.
Worldwide, trachoma is thought to be the most common etiology. Dacryops are considered quite uncommon in other parts of the world; one group reported only 10 patients presenting to their practice in an 18 year period. Dacryops has also been reported in the context of ocular cicatricial pemphigoid and in cases of chemical injury. However, some cases are idiopathic.
Although these lesions have been known to medical science for quite some time, disagreement persists regarding their etiology. Experiments performed around the turn of the last century demonstrated that occlusion of lacrimal system does not result in formation of dacryops. Instead, atrophy of the occluded lacrimal system is seen. Furthermore, pressure within the lacrimal system is physiologically low.Thus, it has been hypothesized that another mechanism must be at work. As high levels of secretory IgA have been found in fluid within these cysts, and strong immunohstochemical staining of cyst wall epithelium has been reported, hypersecretion of IgA into the cyst lumen with resultant osmotic retention of fluid and expansion of the cyst has been proposed as an important step in pathogenesis. Others have proposed that damage to the walls of lacrimal ducts, perhaps secondary to trauma or inflammatory conditions, could predispose them to dilation. The hypothesis that loss of ductal myoepithelium plays a role in pathogenesis, however, is no longer tenable, as imunohistochemical studies have recently shown that the normal lacrimal duct system does not posess a myoepithelial layer.
Patients may complain of a visible mass or swelling of the eyelid. These lesions classically enlarge slowly; however, patients may report a lesion the size of which varies over time, for example enlarging during lacrimation. Aching, irritation, and tenderness have been reported, which are usually mild.
Blepharochalasis or a conjunctival mass can be seen, depending on the anatomical location of the cyst. Ptosis, proptosis, or hypoglobus may result if the cyst is large.
On exam, the cyst can often be directly visualized within the fornix, typically revealing a rubbery, mobile nodule. Size may vary and tenderness may be absent or mild. These lesions will transilluminate, and many sources describe the cysts as having a bluish hue. Dacryops of Wolfring glands, however, is immobile.Most lesions are unilateral Seidel test may be positive near the cyst and has been interpreted as representing preserved, patent lacrimal ductules.
Histologically these lesions are characterized by a fluid-filled cyst, which may be collapsed, surrounded by an epithelial layer; different morphologies, including a single or double layer of cuboidal cells, or a stratified squamous epithelium, with goblet cells, have been reported. Cellular atypia is not seen. Essentially normal lacrimal gland architecture is seen in close proximity. They can be surrounded by a chronic inflammatory infiltrate which is not severe. The most recent extensive histopathological examination, by Jakobiec et al.,, described visible connections of the cystic space with dilated secretory ducts of the lacrimal gland. True apocrine differentiation of the epithelium, although described in prior publications, was not confirmed in this report, and the epithelium was negative for GCDFP-15, an immunohistochemical marker of apocrine differentiation.
Other laboratory testing is not specifically indicated.
Smith and Rootman have noted cases of other orbital cystic lesions which could resemble dacryops, including "dermoid cysts," “laterally located frontal muoceles,” "implantation cyst[s]," "aneurysmal bone cyst[s]," and "lateral rectus muscle cyst[s]," and "parasitic cysts" (such as cysticercosis), and "cysts of the lid adnexal structures." Dacryoadenitis, lymphoproliferative disorders, other lacrimal neoplasms (including pleomorphic adenomas, adenoid cystic carcinomas, squamous cell carcinomas, and mucoepidermoid carcinomas), and vascular malformations should also be ruled out.
This lesion is considered benign, although there is one case report of transformation into squamous cell carcinoma in a patient with a history of multiple cutaneous malignancies. Surgical excision or marsupialization is indicated in patients with symptoms or poor cosmesis. A transconjunctival approach is typically used. Some sources recommend Schirmer's testing and management with marsupialization in patients with low tear production, to avoid exacerbation of aqueous tear deficiency;others have managed these patients non-operatively. In patients with ocular cicatricial pemphigoid, excision through a skin incision has been used to avoid manipulation of compromised conjunctiva. Argon laser photocoagulation has also been described.
Aspiration or drainage is not appropriate as definitive treatment, as it results in rapid recurrence, presumably due to proximity of, or a persistent direct anatomical connection to, the lacrimal gland with its prodigious secretory ability.
Cysts may fistulize or become infected (which can sometimes be seen in the superotemporal fornix as a cyst with an air-fluid level).
Recurrence of the lesion after excision has been described, thought to be a result of incomplete removal. Risks of injury and scarring of the lacrimal gland ductules may also occur.
 Bullock JD, Fleishman JA, Rosset JS. “Lacrimal ductal cysts.” Ophthalmology. 1986 Oct; 93(10): 1355-60. Jakobiec FA, Roh M, Stagner AM, Yoon MK. “Caruncular dacryops.” Cornea. 2015 Jan;34(1): 107-9. O'Duffy D, Watts P. “Wolfring dacryops and needling.” Acta Ophthalmol Scand. 1997 Jun;75(3): 319. *** Seymour Brownstein, Michael W. Belin, Gregory B. Krohel, Richard S. Smith, Garry Condon, Francois Codere. “Orbital dacryops.” Ophthalmology. 1984 91(11): 1424–1428.  Hornblass A, Herschorn BJ. “Lacrimal gland duct cysts.” Ophthalmic Surg 1985; 16:301-6.</ref> Sen DK, Thomas A. “Simple dacryops.” Am J Ophthalmol 1967; 63: 161.*** Bullock JD, Fleishman JA. “Lacrimal gland cysts.” Adv Ophthalmic Plast Reconstr Surg 1984; 3:337-40.***
Eldesouky MA, Elbakary MA1, Sabik S1, Shareef MM2. “Lacrimal fossa lesions: a review of 146 cases in Egypt.” Clin Ophthalmol. 2014 Aug 26;8:1603-9.  Kacerovska D, Michal M, Ricarova R, Frdlikova D, Sosna B, Kazakov DV. “Apocrine secretion in lacrimal gland cysts (dacryops): a common but underrecognized phenomenon.” J Cutan Pathol. 2011 Sep;38(9):720-3.*** PMID: 21752047  Betharia SM, Pushker N, Sharma V, Sen S. “Simple dacryops: a case series and review of the literature.” Ophthalmologica. 2002 Sep-Oct;216(5):372-6. *** PMID: 12424407   Vangveeravong S1, Katz SE, Rootman J, White V. “Tumors arising in the palpebral lobe of the lacrimal gland.” Ophthalmology. 1996 Oct; 103(10):1606-12.
- Salam A, Barrett AW, Malhotra R, Olver J. “Marsupialization for lacrimal ductular cysts (dacryops): a case series.” Ophthal Plast Reconstr Surg. 2012 Jan-Feb;28(1):57-62.
- Remulla HD, Rubin PA.”Giant dacryops in a patient with ocular cicatricial pemphigoid.” Br J Ophthalmol. 1995 Nov; 79(11): 1052-3.
- Morgan-Warren PJ, Madge SN. “Lacrimal duct cyst (dacryops) following ocular chemical injury.” Orbit. 2012 Oct;31(5):335-7.
- Weatherhead RG. “Wolfring dacryops.” Ophthalmology. 1992 Oct;99(10):1575-81.
- Smith S, Rootman J. “Lacrimal ductal cysts. Presentation and management.” Surv Ophthalmol 1986; 30:245-50.
- Lam K, Brownstein S, Jordan DR, Jastrzebski A. “Dacryops: A Series of 5 Cases and a Proposed Pathogenesis.” JAMA Ophthalmol. 2013 Jul;131(7):929-32.
- Jakobiec FA, Zakka FR, Perry LP. “The cytologic composition of dacryops: an immunohistochemical investigation of 15 lesions compared to the normal lacrimal gland.” Am J Ophthalmol. 2013 Feb;155(2):380-396.
- Su GW, Patipa M, Font RL. Primary squamous cell carcinoma arising from an epithelium-lined cyst of the lacrimal gland. Ophthal Plast Reconstr Surg 2005;21:383–5.
- Pantaleoni FB, Spagnolo S, Martini A, et al. Argon laser photocoagulation in the treatment of the palpebral lobe cysts of the lacrimal gland (dacryops). Ophthalmic Surgery and Lasers 1997; 28:690-2.